Publications

Regulation of axon growth by myosin II-dependent mechanocatalysis of cofilin activity.
Zhang XF, Ajeti V, Tsai N, Fereydooni A, Burns W, Murrell M, De La Cruz EM, Forscher P.. Journal of Cell Biology 2019 May; doi: 10.1083/jcb.201910054 Publication Link
Local Arp2/3-dependent actin assembly modulates applied traction force during apCAM adhesion site maturation.
Buck KB, Schaefer AW, Schoonderwoert VT, Creamer MS, Dufresne ER, Forscher P. Molecular Biology of the Cell 2017 Jan; 28 (1): 98-110 Publication Link
Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.
Zhang Y1, Zhang XF2, Fleming MR1, Amiri A3, El-Hassar L1, Surguchev AA1, Hyland C2, Jenkins DP1, Desai R1, Brown MR1, Gazula VR1, Waters MF4, Large CH5, Horvath TL6, Navaratnam D7, Vaccarino FM3, Forscher P8, Kaczmarek LK9.. Cell 2016 April 7; 165 (2): 434-448 Publication Link
Dynamic peripheral traction forces balance stable neurite tension in regenerating Aplysia bag cell neurons.
Hyland C, Mertz AF, Forscher P, Dufresne E. . Scientific Reports 2014 May 14; 4: 4961 Publication Link
Regeneration of Aplysia bag cell neurons is synergistically enhanced by substrate-bound hemolymph proteins and laminin.
Hyland C, Dufresne ER, Forscher P.. Scientific Reports 2014 Apr 11; 4: 4617 Publication Link
Elastic coupling of nascent apCAM adhesions to flowing actin networks
Mejean CO, Schaefer AW, Buck KB, Kress H, Shundrovsky A, Merrill JW, Dufresne ER, Forscher P.. PLoS One 2013 Sep 6; 8 (9): Publication Link
Protein kinase C activation decreases peripheral actin network density and increases central nonmuscle mysin II contractility in neuronal growth cones.
Yang Q, Zhang XF, Van Goor D, Dunn AP, Hyland C, Medeiros N, Forscher P.. Mol. Biol Cell 2013 Oct; 24 (19): 3097-114 Publication Link
Calcineurin-dependent cofilin activation and increased retrograde actin flow drive 5-HT-dependent neurite outgrowth in Aplysia bag cell neurons.
Zhang XF, Hyland C, Van Goor D, Forscher P. Mol Biol Cell 2012 Oct; 23 (24): 4833-48 Publication Link
Arp2/3 complex-dependent actin networks constrain myosin II function in driving retrograde actin flow.
Yang Q, Zhang XF, Pollard TD, Forscher P. J. Cell Biol 2012 Jun; 197 (7): 939-56 Publication Link
The role of actin turnover in retrograde actin network flow in neuronal growth cones.
Van Goor D, Hyland C, Schaefer AW, Forscher P. PloS one 2012 Feb; 7 (2): Publication Link
Membrane tension, myosin force, and actin turnover maintain actin treadmill in the nerve growth cone.
Craig EM, Van Goor D, Forscher P, Mogilner A. Biophys. J 2012 Apr; 102 (7): 1503-1513 Publication Link
Rac1 modulates stimulus-evoked Ca(2+) release in neuronal growth cones via parallel effects on microtubule/endoplasmic reticulum dynamics and reactive oxygen species production.
Zhang XF, Forscher P. Mol Biol Cell 2009 Aug; 20 (16): 3700-3712 Publication Link
Multiplexed force measurements on live cells with holographic optical tewezers.
Jejean CO, Schaefer AW Millman EA, Forscher P, Dufresne ER. Opt Express 2009 Apr 13 ; 17 (8): 6209-6217 Publication Link
Myosin II activity facilitates microtubule bundling in the neuronal growth cone neck
Burnette DT, Ji L, Schaefer AW, Medeiros NA, Danuser G, Forscher P. Dev Cell 2008 Jul; 15 (1): 163-169 Publication Link
Coordination of actin filament and microtubule dynamics during neurite outgrowth.
Schaefer AW, Schoonderwoert VT, Ji L, Mederios N, Danuser G, Forscher P. Dev Cell 2008 Jul; 15 (1): 146-162 Publication Link
Filopodial actin bundles are not necessary for microtubule advance into the peripheral domain of Aplysia neuronal growth cones.
Burnette DT, Schaefer AW, Ji L, Danuser G, Forscher P. Nat Cell Biol 2007 Dec; 9 (12): 1360-1369 Publication Link
Myosin II functions in actin-bundle turnover in neuronal growth cones
Medeiros NA, Burnette DT, Forscher P. Nat. Cell Biol 2006 Mar; 8 (3): 215-226 Publication Link
Intraflagellar transport is required for the vectorial movement of TRPV channels in the ciliary membrane
Qin H, Burnette DT, Bae YK, Forscher P, Barr MM, Rosenbaum JL. Curr. Biol 2005 Sep 20; 15 (18): 1695-1699 Publication Link
Microtubule dynamics are necessary for SCR family kinase-dependent growth cone steering
Suter DM, Schaefer AW, Forscher P. Curr. Biol 2004 Jul 13; 14 (13): 1194-1199 Publication Link
Conserved microtubule-actin interactions in cell movement and morphogenesis
Rodriguez OC, Schaefer AW, Mandato CA, Forscher P, Bement WM, Waterman-Storer CM.. Nat. Cell Biol 2003 Jul; 5 (7): 599-609 Publication Link
Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow
Zhang XF, Schaefer AW, Burnette DT, Schoonderwoert VT, Forscher P.. Neuron 2003 Dec 4; 40 (5): 931-944 Publication Link
Protein kinase C isoforms are translocated to microtubules in neurons
Nakhost A, Kabir N, Forscher P, Sossin WS.. J Biol. Chem 2002 Oct 25; 277 (43): 40633-40639 Publication Link
Filopodia and actin arcs guide the assembly and transport of two populations of microtubules with unique dynamic parameters in neuronal growth cones
Schaefer AW, Kabir N, Forscher P.. J Cell Biol 2002 Jul 8; 158 (1): 139-152 Publication Link
Transmission of growth cone traction force through apCAM-cytoskeletal linkages is regulated by Src family tyrosine kinase activity
Suter DM, Forscher P.. J Cell Biol 2001 Oct 29; 155 (3): 427-438 Publication Link
Protein kinase C activation promotes microtubule advance in neuronal growth cones by increasing average microtubule growth lifetimes
Kabir N, Schaefer AW, Nakhost A, Sossin WS, Forscher P.. J Cell Biol 2001 Mar 5; 152 (5): 1033-1044 Publication Link
Localization of unconventinal myosins V and VI in neuronal growth cones
Suter DM, Espindola FS, Lin CH, Forscher P, Mooseker MS.. J Neurobiol 2000 Feb 15; 42 (3): 370-382 Publication Link
Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance
Suter DM, Forscher P.. J Neurobiol 2000 Aug; 44 (2): 97-113 Publication Link
A diffusion barrier maintains distribution of membrane proteins in polarized neurons
Winckler B, Forscher P, Mellman I.. Nature 1999 Feb 25; 397 (6721): 698-701 Publication Link
Binding of protein kinase C isoforms to actin in Aplysia
Nakhost A, Forscher P, Sossin WS.. J Neurochem 1998 Sep; 71 (3): 1221-1231 Publication Link
An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance
Suter DM, Forscher P.. Curr Opin Neurobiol 1998 Feb; 8 (1): 106-116 Publication Link
The Ig superfamily cell adhesion molecule, apCAM, mediates growth cone steering by substrate-cytoskeletal coupling
Suter Dm, Errante LD, Belotserkovsky V, Forscher P.. J Cell Biol 1998 Apr 6; 141 (1): 227.240 Publication Link
Three flagellar motilies in Chlamydomonas unrelated to flagellar beating. Video supplement
Kozminski KG, Forscher P, Rosenbaum JL. Cell Motil Cytoskeleton 1998 39 (4): 347-348
Myosin drives retrograde F-actin flow in neuronal growth cones
Lin CH, Espreafico EM, Mooseker MS, Forscher P. Biol Bull 1997 Feb; 192 (1): 183-185
An Aplysia cell adhesion molecule associated with site-directed actin filament assembly in neuronal growth cones
Thompson C, Lin CH, Forscher P. J Cell Sci 1996 Dec; 109 (Pt 12): 2843-2854 Publication Link
Myosin drives retrograde F-actin flow in neuronal growth cones
Lin CH, Espreafico EM, Mooseker MS, Forscher P. Neuron 1996 Apr; 16 (4): 769-782 Publication Link
Growth cone advance in inversely proportional to retrograde F-actin flow
Lin CH, Forscher P. Neuron 1995 Apr; 14 (4): 763-771 Publication Link
In vitro motility of immunoadsorbed brain myosin-V using a Limulus acrosomal process and opitcal tweezer-based asssay
Wolenski JS, Cheney RE, Mooseker MS, Forscher P. J Cell Sci 1995 Apr; 108 (Pt 4): 1489-1496 Publication Link
Cytoskeletal reorganization underlying growth cone motility
Lin CH, Thompson CA, Forscher P. Curr Opin Neurobiol 1994 Oct; 4 (5): 640-647
Cyclic AMP modulates fast axonal transport in Aplysia bag cell neurons by increasing the probability of single organelle movement
Azhderian EM, Hefner D, Lin CH, Kaczmarek LK, Forscher P. Neuron 1994 Jun; 12 (6): 1223-1233 Publication Link
In vitro motilities of the unconventional myosins, brush border myosin-I, and chick brain myosin-V exhibit assay-dependent differences in velocity
Wolenski JS, Cheney RE, Forscher P, Mooseker MS. J Exp Zool 1993 Sep; 267 (1): 33-39
Brain myosin-V is a two headed unconventional myosin with motor activity
Cheney RE, O'Shea MK, Heuser JE, Coelho MV, Wolenski JS, Espreafico EM, Forscher P, Larson REm, Mooseker MS. Cell 1993 Oct; 75 (1): 13-23
A novel cytoskeletal structure involved in purse string wound closure and cell polarity maintenance
Bement WM, Forscher P, Mooseker MS. J Cell Biol 1993 May; 121 (3): 565-578 Publication Link
A motility in the eukaryotic flagellum unrelated to flagellar beating
Kozminski KG, Johnson KA, Forscher P, Rosenbaum JL. Proc Natl Acad Sci USA 1993 Jun; 90 (12): 5519-5523 Publication Link
Cytoskeletal remodeling during growth cone-target interactions
Lin CH, Forscher P. J Cell Biol 1993 Jun; 121 (6): 1369-1383 Publication Link
Calcium-calmodulin and regulation of brush border myosin-I MgATPase and mechanochemistry
Wolenski JS, Hayden SM, Forscher P, Mooseker MS. J Cell Biol 1993 Aug; 122 (3): 614-621 Publication Link
Novel form of growth cone motility involving site-directed actin filament assembly
Forscher P, Lin CH, Thompson C. Nature 1992 Jun 11; 357 (6378): 515-518 Publication Link
Calcium and polyphosphoinositide control of cytoskeletal dynamics
Forscher P. Trends Neurosci 1989 Nov; 12 (11): 468-474 Publication Link
Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone
Forscher P, Smith SJ. J Cell Biol 1988 Oct; 107 (4): 1505-1516 Publication Link
Cyclic AMP induces changes in distribution and transport of organelles within growth cones of Aplysia bag cell neurons
Forscher P, Kaczmarek LK, Buchanan JA, Smith SJ. J Neurosci 1987 Nov; 7 (11): 3600-3611 Publication Link
Noradrenaline modulates calcium channels in avian dorsal root ganglion cells through tight receptor-channel coupling
Forscher P, Oxford GS, Schulz D. J Physiol 1986 Oct; 379 131-44 Publication Link
Modulation of calcium channels by norepinephrine in internally dialyzed avian sensory neurons
Forscher P, Oxford GS. J Gen Physiol 1985 May; 85 (5): 743-763 Publication Link